Beilstein J. Org. Chem.2010,6, No. 27, doi:10.3762/bjoc.6.27
-tetrazole (6) and its Negishi coupling with aryl bromide 5 are the key steps of the synthesis. This method overcomes many of the drawbacks associated with previously reported syntheses.
Keywords: antihypertensivetherapy; aryl bromide; Negishi coupling; tetrazole; valsartan; Introduction
Valsartan (Figure